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KMID : 0614620000360030348
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Korean Journal of Gastroenterology
2000 Volume.36 No. 3 p.348 ~ p.360
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Expression of MUC1, MUC2 and MUC5AC in Gastric Epithelial Dysplasia and Intestinal-Type Gastric Carcinoma
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Kim Sun-Taek
Han Sang-Young
Choi Seok-Reyol
Kim Jong-Seong
Jeong Jin-Sook
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Abstract
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Background/Aims : The transition from intestinal metaplasia to adenocarcinoma is characterized by qualitative and quantitative alterations of mucin core peptides. The purposes of this study were to evaluate expression of mucin core peptides known as prognostic factors in gastric epithelial dysplasia to intestinal-type gastric carcinoma.
Methods : Immunohistochemical studies of 3 antigens associated with alteration of mucin glycoprotein (MUC1, MUC2, MUC5AC) were performed for 63 gastric carcinoma tissues (EGC: 23 cases, AGC: 40 cases) and 54 gastric epithelial dysplasia tissues obtained from Janurary 1997 to December 1997 in Dong-A University Hospital.
Results : Expressions of MUC1, MUC2 and MUC5AC peptides were significantly increased. Distribution and density of them were also significantly increased in progression from gastric dysplasia to advanced intestinal-type gastric cancer (p=0.001). The incidence of lymph node metastasis was significantly increased according to the increase in expression of MUC2 and MUC5AC peptides. The expression of MUC2 and MUC5AC peptides and extensive staining pattern of MUC1, MUC2 and MUC5AC peptides were more increased in carcinomas with deep invasion.
Conclusions : These results suggest that the alterations in expression of the mucin peptides may be correlated with prognostic factors and can predict progression from gastric epithelial dysplasia to intestinal-type gastric cancer.
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KEYWORD
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MUC1, MUC2, MUC5AC, Gastric cancer, Gastric epithelial dysplasia
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